Psychoanalytic interventions occur in manualized short-term psychodynamic psychotherapy through the Regulation Focused Psychotherapy approach. In this presentation, Drs. Leon Hoffman and Timothy Rice will review the history of the psychoanalytic technique of interpreting defenses against painful affect with children, demonstrate its effectiveness in the case history of Philip, a six-year-and-five-month old boy who was felt to be autistic, and introduce the Regulation Focused Psychotherapy project. A discussion on the benefits to the analytic and academic communities of incorporating psychoanalytic interventions within testable manualized approaches as well as models for formulation and intervention in children with autism spectrum disorders will follow with audience participation and conversation.